Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population

Lyle G. Best; Richa Saxena; Cindy M. Anderson; Michael R. Barnes; Hakon Hakonarson; Gilbert Falcon; Candelaria Martin; Berta Almoguera Castillo; Ananth Karumanchi; Kylie Keplin; Nichole Pearson; Felicia Lamb; Shellee Bercier; Brendan J. Keating

doi:10.1371/journal.pone.0071231

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Open Access

Peer-reviewed

Research Article

Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population

Lyle G. Best ,

* E-mail: lbest@restel.com

Affiliations Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Richa Saxena,

Affiliation Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Cindy M. Anderson,

Affiliation College of Nursing, University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Michael R. Barnes,

Affiliation William Harvey Research Institute, Barts and London School of Medicine and Dentistry, London, United Kingdom
⨯
Hakon Hakonarson,

Affiliation Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Gilbert Falcon,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Candelaria Martin,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Berta Almoguera Castillo,

Affiliation Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Ananth Karumanchi,

Affiliation Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kylie Keplin,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Nichole Pearson,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Felicia Lamb,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Shellee Bercier,

Affiliation Science Department, Turtle Mountain Community College, Belcourt, North Dakota, United States of America
⨯
Brendan J. Keating

Affiliation Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯

Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population

Lyle G. Best,
Richa Saxena,
Cindy M. Anderson,
Michael R. Barnes,
Hakon Hakonarson,
Gilbert Falcon,
Candelaria Martin,
Berta Almoguera Castillo,
Ananth Karumanchi,
Kylie Keplin

Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0071231

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Single nucleotide polymorphisms
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C-reactive proteins
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Alleles
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Variant genotypes
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Medical risk factors
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Preeclampsia
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Untranslated regions
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Hypertensive disorders in pregnancy
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