Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients

Henricus A. M. Mutsaers; Udo F. H. Engelke; Martijn J. G. Wilmer; Jack F. M. Wetzels; Ron A. Wevers; Lambertus P. van den Heuvel; Joost G. Hoenderop; Rosalinde Masereeuw

doi:10.1371/journal.pone.0071199

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Peer-reviewed

Research Article

Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients

Henricus A. M. Mutsaers,

Affiliations Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands, Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Udo F. H. Engelke,

Affiliation Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Martijn J. G. Wilmer,

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Jack F. M. Wetzels,

Affiliation Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Ron A. Wevers,

Affiliation Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Lambertus P. van den Heuvel,

Affiliations Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Department of Pediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Department of Pediatrics, Catholic University Leuven, Leuven, Belgium
⨯
Joost G. Hoenderop,

Affiliation Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Rosalinde Masereeuw

* E-mail: r.masereeuw@pharmtox.umcn.nl

Affiliation Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯

Optimized Metabolomic Approach to Identify Uremic Solutes in Plasma of Stage 3–4 Chronic Kidney Disease Patients

Henricus A. M. Mutsaers,
Udo F. H. Engelke,
Martijn J. G. Wilmer,
Jack F. M. Wetzels,
Ron A. Wevers,
Lambertus P. van den Heuvel,
Joost G. Hoenderop,
Rosalinde Masereeuw

Published: August 2, 2013
https://doi.org/10.1371/journal.pone.0071199

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Chronic kidney disease
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Toxins
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Metabolites
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Acetonitrile
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Blood plasma
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Protein metabolism
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