CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

Shinsuke Itoh; Takako Hattori; Nao Tomita; Eriko Aoyama; Yasutaka Yutani; Takashi Yamashiro; Masaharu Takigawa

doi:10.1371/journal.pone.0071156

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Peer-reviewed

Research Article

CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

Shinsuke Itoh,

Affiliations Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Takako Hattori ,

* E-mail: hattorit@md.okayama-u.ac.jp (TH); Takigawa@md.okayama-u.ac.jp (MT)

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Nao Tomita,

Affiliations Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Eriko Aoyama,

Affiliation Biodental Research Center, Okayama University Dental School, Okayama, Japan
⨯
Yasutaka Yutani,

Affiliation Yutani Orthopaedic Clinic, Kobe, Japan
⨯
Takashi Yamashiro,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Masaharu Takigawa

* E-mail: hattorit@md.okayama-u.ac.jp (TH); Takigawa@md.okayama-u.ac.jp (MT)

Affiliation Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯

CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes

Shinsuke Itoh,
Takako Hattori,
Nao Tomita,
Eriko Aoyama,
Yasutaka Yutani,
Takashi Yamashiro,
Masaharu Takigawa

Published: August 12, 2013
https://doi.org/10.1371/journal.pone.0071156

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