Lentiviral Vector-Mediated Gradients of GDNF in the Injured Peripheral Nerve: Effects on Nerve Coil Formation, Schwann Cell Maturation and Myelination

Ruben Eggers; Fred de Winter; Stefan A. Hoyng; Kasper C. D. Roet; Erich M. Ehlert; Martijn J. A. Malessy; Joost Verhaagen; Martijn R. Tannemaat

doi:10.1371/journal.pone.0071076

Loading metrics

Open Access

Peer-reviewed

Research Article

Lentiviral Vector-Mediated Gradients of GDNF in the Injured Peripheral Nerve: Effects on Nerve Coil Formation, Schwann Cell Maturation and Myelination

Ruben Eggers,

Affiliation Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands
⨯
Fred de Winter,

Affiliations Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands, Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
⨯
Stefan A. Hoyng,

Affiliations Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands, Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
⨯
Kasper C. D. Roet,

Affiliation Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands
⨯
Erich M. Ehlert,

Affiliation Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands
⨯
Martijn J. A. Malessy,

Affiliations Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands, Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
⨯
Joost Verhaagen,

Affiliations Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognition Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
⨯
Martijn R. Tannemaat

* E-mail: m.r.tannemaat@lumc.nl

Affiliations Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
⨯

Lentiviral Vector-Mediated Gradients of GDNF in the Injured Peripheral Nerve: Effects on Nerve Coil Formation, Schwann Cell Maturation and Myelination

Ruben Eggers,
Fred de Winter,
Stefan A. Hoyng,
Kasper C. D. Roet,
Erich M. Ehlert,
Martijn J. A. Malessy,
Joost Verhaagen,
Martijn R. Tannemaat

Published: August 12, 2013
https://doi.org/10.1371/journal.pone.0071076

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Axons
Is the Subject Area "Axons" applicable to this article?

Thanks for your feedback.
Sciatic nerves
Is the Subject Area "Sciatic nerves" applicable to this article?

Thanks for your feedback.
Nerves
Is the Subject Area "Nerves" applicable to this article?

Thanks for your feedback.
Schwann cells
Is the Subject Area "Schwann cells" applicable to this article?

Thanks for your feedback.
Nerve fibers
Is the Subject Area "Nerve fibers" applicable to this article?

Thanks for your feedback.
Nerve regeneration
Is the Subject Area "Nerve regeneration" applicable to this article?

Thanks for your feedback.
Viral vectors
Is the Subject Area "Viral vectors" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.