A Human In Vitro Whole Blood Assay to Predict the Systemic Cytokine Response to Therapeutic Oligonucleotides Including siRNA

• Christoph Coch ,

  Contributed equally to this work with: Christoph Coch, Christian Lück, Gunther Hartmann, Martin Schlee

  * E-mail: ccoch@uni-bonn.de

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Christian Lück ,

  Contributed equally to this work with: Christoph Coch, Christian Lück, Gunther Hartmann, Martin Schlee

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Anna Schwickart,

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Bastian Putschli,

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Marcel Renn,

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Tobias Höller,

  Affiliation Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Winfried Barchet,

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Gunther Hartmann ,

  Contributed equally to this work with: Christoph Coch, Christian Lück, Gunther Hartmann, Martin Schlee

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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• Martin Schlee

  Contributed equally to this work with: Christoph Coch, Christian Lück, Gunther Hartmann, Martin Schlee

  Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, Bonn, Germany

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