Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

Eva-Verena Schaible; Arne Steinsträßer; Antje Jahn-Eimermacher; Clara Luh; Anne Sebastiani; Frida Kornes; Dana Pieter; Michael K. Schäfer; Kristin Engelhard; Serge C. Thal

doi:10.1371/journal.pone.0071056

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Open Access

Peer-reviewed

Research Article

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

Eva-Verena Schaible,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Arne Steinsträßer,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Antje Jahn-Eimermacher,

Affiliation Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Clara Luh,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Anne Sebastiani,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Frida Kornes,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Dana Pieter,

Affiliation Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Michael K. Schäfer,

Affiliations Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Focus Program Translational Neuroscience, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Kristin Engelhard,

Affiliations Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Focus Program Translational Neuroscience, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Serge C. Thal

* E-mail: thal@uni-mainz.de

Affiliations Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Focus Program Translational Neuroscience, Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⨯

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

Eva-Verena Schaible,
Arne Steinsträßer,
Antje Jahn-Eimermacher,
Clara Luh,
Anne Sebastiani,
Frida Kornes,
Dana Pieter,
Michael K. Schäfer,
Kristin Engelhard,
Serge C. Thal

Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0071056

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