MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

Xiangyan Li; Yi-Ting Chen; Sajni Josson; Nishit K. Mukhopadhyay; Jayoung Kim; Michael R. Freeman; Wen-Chin Huang

doi:10.1371/journal.pone.0070987

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Peer-reviewed

Research Article

MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

Xiangyan Li,

Affiliation Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Yi-Ting Chen,

Affiliation Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Sajni Josson,

Affiliation Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Nishit K. Mukhopadhyay,

Affiliation Cancer Biology Program, Departments of Surgery, Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Jayoung Kim,

Affiliation Cancer Biology Program, Departments of Surgery, Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Michael R. Freeman,

Affiliation Cancer Biology Program, Departments of Surgery, Medicine and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Wen-Chin Huang

* E-mail: wen-chin.huang@cshs.org

Affiliation Uro-Oncology Research Program, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯

MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

Xiangyan Li,
Yi-Ting Chen,
Sajni Josson,
Nishit K. Mukhopadhyay,
Jayoung Kim,
Michael R. Freeman,
Wen-Chin Huang

Published: August 9, 2013
https://doi.org/10.1371/journal.pone.0070987

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MicroRNAs
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Cholesterol
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Cell proliferation
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Fatty acids
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Transfection
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