A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold

Adela Rendón-Ramírez; Manish Shukla; Masataka Oda; Sandeep Chakraborty; Renu Minda; Abhaya M. Dandekar; Bjarni Ásgeirsson; Félix M. Goñi; Basuthkar J. Rao

doi:10.1371/journal.pone.0070923

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Research Article

A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold

Adela Rendón-Ramírez ,

Contributed equally to this work with: Adela Rendón-Ramírez, Manish Shukla, Masataka Oda, Sandeep Chakraborty

Affiliation Unidad de Biofísica (Consejo Superior de Investigaciones Científicas, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea) and Departamento de Bioquímica, Universidad del País Vasco, Bilbao, Spain
⨯
Manish Shukla ,

Contributed equally to this work with: Adela Rendón-Ramírez, Manish Shukla, Masataka Oda, Sandeep Chakraborty

Affiliation Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, India
⨯
Masataka Oda ,

Contributed equally to this work with: Adela Rendón-Ramírez, Manish Shukla, Masataka Oda, Sandeep Chakraborty

Affiliation Department of Microbiology, Faculty of Pharmaceutical Science, Tokushima Bunri University, Tokushima, Japan
⨯
Sandeep Chakraborty ,

Contributed equally to this work with: Adela Rendón-Ramírez, Manish Shukla, Masataka Oda, Sandeep Chakraborty

* E-mail: sanchak@gmail.com

Affiliation Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
⨯
Renu Minda,

Affiliation Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
⨯
Abhaya M. Dandekar,

Affiliation Plant Sciences Department, University of California, Davis, Davis, California, United States of America
⨯
Bjarni Ásgeirsson,

Affiliation Science Institute, Department of Biochemistry, University of Iceland, Dunhaga, Reykjavik, Iceland
⨯
Félix M. Goñi,

Affiliation Unidad de Biofísica (Consejo Superior de Investigaciones Científicas, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea) and Departamento de Bioquímica, Universidad del País Vasco, Bilbao, Spain
⨯
Basuthkar J. Rao

Affiliation Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
⨯

A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold

Adela Rendón-Ramírez,
Manish Shukla,
Masataka Oda,
Sandeep Chakraborty,
Renu Minda,
Abhaya M. Dandekar,
Bjarni Ásgeirsson,
Félix M. Goñi,
Basuthkar J. Rao

Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0070923

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Proteases
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Serine proteases
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Bacillus cereus
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Electrostatics
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Trypsin inhibitors
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Outer membrane proteins
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Protein structure databases
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