Comparative Genomic Analysis of Brucella melitensis Vaccine Strain M5 Provides Insights into Virulence Attenuation

Hai Jiang; Pengcheng Du; Wen Zhang; Heng Wang; Hongyan Zhao; Dongri Piao; Guozhong Tian; Chen Chen; Buyun Cui

doi:10.1371/journal.pone.0070852

Loading metrics

Open Access

Peer-reviewed

Research Article

Comparative Genomic Analysis of Brucella melitensis Vaccine Strain M5 Provides Insights into Virulence Attenuation

Hai Jiang ,

Contributed equally to this work with: Hai Jiang, Pengcheng Du

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Pengcheng Du ,

Contributed equally to this work with: Hai Jiang, Pengcheng Du

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Wen Zhang,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Heng Wang,

Affiliation Department of Endemic and Parasitic Diseases Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou, China
⨯
Hongyan Zhao,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Dongri Piao,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Guozhong Tian,

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Chen Chen ,

* E-mail: chenchen@icdc.cn (CC); cuibuyun@icdc.cn (BC)

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯
Buyun Cui

* E-mail: chenchen@icdc.cn (CC); cuibuyun@icdc.cn (BC)

Affiliation State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Beijing, China
⨯

Comparative Genomic Analysis of Brucella melitensis Vaccine Strain M5 Provides Insights into Virulence Attenuation

Hai Jiang,
Pengcheng Du,
Wen Zhang,
Heng Wang,
Hongyan Zhao,
Dongri Piao,
Guozhong Tian,
Chen Chen,
Buyun Cui

Published: August 14, 2013
https://doi.org/10.1371/journal.pone.0070852

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Brucella
Is the Subject Area "Brucella" applicable to this article?

Thanks for your feedback.
Virulence factors
Is the Subject Area "Virulence factors" applicable to this article?

Thanks for your feedback.
Gene prediction
Is the Subject Area "Gene prediction" applicable to this article?

Thanks for your feedback.
Vaccines
Is the Subject Area "Vaccines" applicable to this article?

Thanks for your feedback.
Genome analysis
Is the Subject Area "Genome analysis" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Secretion systems
Is the Subject Area "Secretion systems" applicable to this article?

Thanks for your feedback.