Comparison of IHC, FISH and RT-PCR Methods for Detection of ALK Rearrangements in 312 Non-Small Cell Lung Cancer Patients in Taiwan

Yi-Cheng Wu; Il-Chi Chang; Chi-Liang Wang; Tai-Di Chen; Ya-Ting Chen; Hui-Ping Liu; Yen Chu; Yu-Ting Chiu; Tzu-Hua Wu; Li-Hui Chou; Yi-Rong Chen; Shiu-Feng Huang

doi:10.1371/journal.pone.0070839

Loading metrics

Open Access

Peer-reviewed

Research Article

Comparison of IHC, FISH and RT-PCR Methods for Detection of ALK Rearrangements in 312 Non-Small Cell Lung Cancer Patients in Taiwan

Yi-Cheng Wu ,

Contributed equally to this work with: Yi-Cheng Wu, Il-Chi Chang

Affiliation Department of CardioVascular and Thoracic Surgery, Chang Gung Memorial Hospital at Linko, and Chang Gung University College of Medicine, Taoyuan, Taiwan
⨯
Il-Chi Chang ,

Contributed equally to this work with: Yi-Cheng Wu, Il-Chi Chang

Affiliation Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
⨯
Chi-Liang Wang,

Affiliation Division of Pulmonology, Department of Medicine, Chang Gung Memorial Hospital at Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
⨯
Tai-Di Chen,

Affiliation Department of Pathology, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan
⨯
Ya-Ting Chen,

Affiliation Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
⨯
Hui-Ping Liu,

Affiliation Department of CardioVascular and Thoracic Surgery, Chang Gung Memorial Hospital at Linko, and Chang Gung University College of Medicine, Taoyuan, Taiwan
⨯
Yen Chu,

Affiliation Department of CardioVascular and Thoracic Surgery, Chang Gung Memorial Hospital at Linko, and Chang Gung University College of Medicine, Taoyuan, Taiwan
⨯
Yu-Ting Chiu,

Affiliation Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
⨯
Tzu-Hua Wu,

Affiliation Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
⨯
Li-Hui Chou,

Affiliation Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
⨯
Yi-Rong Chen,

Affiliation Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
⨯
Shiu-Feng Huang

* E-mail: sfhuang@nhri.org.tw

Affiliations Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan, Department of Pathology, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan, Department of Pathology, Buddhist Tzu-Chi Medical Center, Taipei Branch, New Taipei, Taiwan, Department of Medicine, Tzu-Chi University College of Medicine, Hualien, Taiwan
⨯

Comparison of IHC, FISH and RT-PCR Methods for Detection of ALK Rearrangements in 312 Non-Small Cell Lung Cancer Patients in Taiwan

Yi-Cheng Wu,
Il-Chi Chang,
Chi-Liang Wang,
Tai-Di Chen,
Ya-Ting Chen,
Hui-Ping Liu,
Yen Chu,
Yu-Ting Chiu,
Tzu-Hua Wu,
Li-Hui Chou

Published: August 7, 2013
https://doi.org/10.1371/journal.pone.0070839

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Reverse transcriptase-polymerase chain reaction
Is the Subject Area "Reverse transcriptase-polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.
Fusion genes
Is the Subject Area "Fusion genes" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Fluorescent in situ hybridization
Is the Subject Area "Fluorescent in situ hybridization" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.