An NO Donor Approach to Neuroprotective and Procognitive Estrogen Therapy Overcomes Loss of NO Synthase Function and Potentially Thrombotic Risk

Lawren VandeVrede; Ramy Abdelhamid; Zhihui Qin; Jaewoo Choi; Sujeewa Piyankarage; Jia Luo; John Larson; Brian M. Bennett; Gregory R. J. Thatcher

doi:10.1371/journal.pone.0070740

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Peer-reviewed

Research Article

An NO Donor Approach to Neuroprotective and Procognitive Estrogen Therapy Overcomes Loss of NO Synthase Function and Potentially Thrombotic Risk

Lawren VandeVrede,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Ramy Abdelhamid,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Zhihui Qin,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Jaewoo Choi,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Sujeewa Piyankarage,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Jia Luo,

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
John Larson,

Affiliation Department of Psychiatry, Neuropsychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Brian M. Bennett,

Affiliation Department of Biomedical and Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada
⨯
Gregory R. J. Thatcher

* E-mail: thatcher@uic.edu

Affiliation Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

An NO Donor Approach to Neuroprotective and Procognitive Estrogen Therapy Overcomes Loss of NO Synthase Function and Potentially Thrombotic Risk

Lawren VandeVrede,
Ramy Abdelhamid,
Zhihui Qin,
Jaewoo Choi,
Sujeewa Piyankarage,
Jia Luo,
John Larson,
Brian M. Bennett,
Gregory R. J. Thatcher

Published: August 16, 2013
https://doi.org/10.1371/journal.pone.0070740

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