The Polymorphic AluYb8 Insertion in the MUTYH Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content

Wenwen Guo; Bixia Zheng; Zhenming Cai; Lizhi Xu; Dong Guo; Lili Cao; Yaping Wang

doi:10.1371/journal.pone.0070718

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Peer-reviewed

Research Article

The Polymorphic AluYb8 Insertion in the MUTYH Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content

Wenwen Guo,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China, The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
⨯
Bixia Zheng,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
⨯
Zhenming Cai,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
⨯
Lizhi Xu,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
⨯
Dong Guo,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
⨯
Lili Cao,

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
⨯
Yaping Wang

* E-mail: wangyap@nju.edu.cn

Affiliations Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, China, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China, The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
⨯

The Polymorphic AluYb8 Insertion in the MUTYH Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content

Wenwen Guo,
Bixia Zheng,
Zhenming Cai,
Lizhi Xu,
Dong Guo,
Lili Cao,
Yaping Wang

Published: August 6, 2013
https://doi.org/10.1371/journal.pone.0070718

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Mitochondrial DNA
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Mitochondria
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Alu elements
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Polymerase chain reaction
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Homozygosity
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Protein expression
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Introns
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Variant genotypes
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