Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

Thomas A. Munro; Xi-Ping Huang; Carmela Inglese; Maria Grazia Perrone; Ashlee Van't Veer; F. Ivy Carroll; Cécile Béguin; William A. Carlezon Jr; Nicola A. Colabufo; Bruce M. Cohen; Bryan L. Roth

doi:10.1371/journal.pone.0070701

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Peer-reviewed

Research Article

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

Thomas A. Munro ,

* E-mail: thomas@munro.com

Affiliations McLean Hospital, Belmont, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, Australia
⨯
Xi-Ping Huang,

Affiliation National Institute of Mental Health Psychoactive Drug Screening Program and Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Carmela Inglese,

Affiliation Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, Bari, Italy
⨯
Maria Grazia Perrone,

Affiliation Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, Bari, Italy
⨯
Ashlee Van't Veer,

Affiliations McLean Hospital, Belmont, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
F. Ivy Carroll,

Affiliation Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, North Carolina, United States of America
⨯
Cécile Béguin,

Affiliations McLean Hospital, Belmont, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
William A. Carlezon Jr,

Affiliations McLean Hospital, Belmont, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Nicola A. Colabufo,

Affiliation Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari, Bari, Italy
⨯
Bruce M. Cohen,

Affiliations McLean Hospital, Belmont, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Bryan L. Roth

Affiliation National Institute of Mental Health Psychoactive Drug Screening Program and Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

Thomas A. Munro,
Xi-Ping Huang,
Carmela Inglese,
Maria Grazia Perrone,
Ashlee Van't Veer,
F. Ivy Carroll,
Cécile Béguin,
William A. Carlezon Jr,
Nicola A. Colabufo,
Bruce M. Cohen

Published: August 14, 2013
https://doi.org/10.1371/journal.pone.0070701

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