Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Mary E. Irwin; Laura D. Nelson; Janice M. Santiago-O’Farrill; Phillip D. Knouse; Claudia P. Miller; Shana L. Palla; Doris R. Siwak; Gordon B. Mills; Zeev Estrov; Shulin Li; Steven M. Kornblau; Dennis P. Hughes; Joya Chandra

doi:10.1371/journal.pone.0070608

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Peer-reviewed

Research Article

Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Mary E. Irwin,

Affiliation Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Laura D. Nelson,

Affiliation Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Janice M. Santiago-O’Farrill,

Affiliations Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯
Phillip D. Knouse,

Affiliation Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Claudia P. Miller,

Affiliations Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯
Shana L. Palla,

Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Doris R. Siwak,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Gordon B. Mills,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zeev Estrov,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Shulin Li,

Affiliation Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Steven M. Kornblau,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Dennis P. Hughes,

Affiliations Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯
Joya Chandra

* E-mail: jchandra@mdanderson.org

Affiliations Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯

Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Mary E. Irwin,
Laura D. Nelson,
Janice M. Santiago-O’Farrill,
Phillip D. Knouse,
Claudia P. Miller,
Shana L. Palla,
Doris R. Siwak,
Gordon B. Mills,
Zeev Estrov,
Shulin Li

Published: August 1, 2013
https://doi.org/10.1371/journal.pone.0070608

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Apoptosis
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Signal inhibition
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Protein expression
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