Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes

May Shawi; Tsz Wai Chu; Veronica Martinez-Marignac; Y. Yu; Sergei M. Gryaznov; James B. Johnston; Susan P. Lees-Miller; Sarit E. Assouline; Chantal Autexier; Raquel Aloyz

doi:10.1371/journal.pone.0070428

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Open Access

Peer-reviewed

Research Article

Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes

May Shawi,

Affiliations Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada, Bloomfield Centre for Research in Ageing, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Tsz Wai Chu,

Affiliations Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Bloomfield Centre for Research in Ageing, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Veronica Martinez-Marignac,

Affiliation Lady Davis Institute for Medical Research & Cancer Segal Center, Jewish General Hospital, Montreal, Quebec, Canada
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Y. Yu,

Affiliation University of Calgary, Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada
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Sergei M. Gryaznov,

Affiliation Geron Corporation, Menlo Park, California, United States of America
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James B. Johnston,

Affiliation Manitoba Institute of Cell Biology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada
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Susan P. Lees-Miller,

Affiliation University of Calgary, Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, Calgary, Alberta, Canada
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Sarit E. Assouline,

Affiliations Oncology Department, McGill University, Montreal, Quebec, Canada, Lady Davis Institute for Medical Research & Cancer Segal Center, Jewish General Hospital, Montreal, Quebec, Canada
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Chantal Autexier,

Affiliations Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada, Bloomfield Centre for Research in Ageing, Jewish General Hospital, Montreal, Quebec, Canada
⨯
Raquel Aloyz

* E-mail: raquel.aloyz@mcgill.ca

Affiliations Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Oncology Department, McGill University, Montreal, Quebec, Canada, Lady Davis Institute for Medical Research & Cancer Segal Center, Jewish General Hospital, Montreal, Quebec, Canada
⨯

Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes

May Shawi,
Tsz Wai Chu,
Veronica Martinez-Marignac,
Y. Yu,
Sergei M. Gryaznov,
James B. Johnston,
Susan P. Lees-Miller,
Sarit E. Assouline,
Chantal Autexier,
Raquel Aloyz

Published: July 29, 2013
https://doi.org/10.1371/journal.pone.0070428

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