Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data

• Fumiyoshi Yamashita ,

  * E-mail: yama@pharm.kyoto-u.ac.jp

  Affiliation Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

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• Yukako Sasa,

  Affiliation Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

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• Shuya Yoshida,

  Affiliation Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

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• Akihiro Hisaka,

  Affiliation Department of Pharmacology and Pharmacokinetics, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

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• Yoshiyuki Asai,

  Affiliation Open Biology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan

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• Hiroaki Kitano,

  Affiliations Open Biology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan, Sony Computer Science Laboratories, Inc, Tokyo, Japan

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• Mitsuru Hashida,

  Affiliations Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan, Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan

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• Hiroshi Suzuki

  Affiliation Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

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