Comparative Study of Two Box H/ACA Ribonucleoprotein Pseudouridine-Synthases: Relation between Conformational Dynamics of the Guide RNA, Enzyme Assembly and Activity

Jean-Baptiste Fourmann; Anne-Sophie Tillault; Magali Blaud; Fabrice Leclerc; Christiane Branlant; Bruno Charpentier

doi:10.1371/journal.pone.0070313

Loading metrics

Open Access

Peer-reviewed

Research Article

Comparative Study of Two Box H/ACA Ribonucleoprotein Pseudouridine-Synthases: Relation between Conformational Dynamics of the Guide RNA, Enzyme Assembly and Activity

Jean-Baptiste Fourmann ,

Contributed equally to this work with: Jean-Baptiste Fourmann, Anne-Sophie Tillault, Magali Blaud

Current address: Department of Cellular Biochemistry, Max-Planck-Institute of Biophysical Chemistry (MPI-MG), Göttingen, Germany

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯
Anne-Sophie Tillault ,

Contributed equally to this work with: Jean-Baptiste Fourmann, Anne-Sophie Tillault, Magali Blaud

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯
Magali Blaud ,

Contributed equally to this work with: Jean-Baptiste Fourmann, Anne-Sophie Tillault, Magali Blaud

Current address: Laboratoire de Cristallographie et RMN Biologiques, Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université Paris Descartes, Faculté de Pharmacie, Paris, France

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯
Fabrice Leclerc,

Current address: Institut de Génétique et Microbiologie, Unité Mixte de Recherche Centre National de la Recherche Scientifique-Université Paris-Sud, Orsay, France

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯
Christiane Branlant,

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯
Bruno Charpentier

* E-mail: bruno.charpentier@univ-lorraine.fr

Affiliation Laboratoire Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Unité Mixte de Recherche Centre National de la Recherche Scientifique - Université de Lorraine, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
⨯

Comparative Study of Two Box H/ACA Ribonucleoprotein Pseudouridine-Synthases: Relation between Conformational Dynamics of the Guide RNA, Enzyme Assembly and Activity

Jean-Baptiste Fourmann,
Anne-Sophie Tillault,
Magali Blaud,
Fabrice Leclerc,
Christiane Branlant,
Bruno Charpentier

Published: July 29, 2013
https://doi.org/10.1371/journal.pone.0070313

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ribonucleoproteins
Is the Subject Area "Ribonucleoproteins" applicable to this article?

Thanks for your feedback.
Small nucleolar RNA
Is the Subject Area "Small nucleolar RNA" applicable to this article?

Thanks for your feedback.
RNA structure
Is the Subject Area "RNA structure" applicable to this article?

Thanks for your feedback.
RNA-binding proteins
Is the Subject Area "RNA-binding proteins" applicable to this article?

Thanks for your feedback.
Electrophoretic mobility shift assay
Is the Subject Area "Electrophoretic mobility shift assay" applicable to this article?

Thanks for your feedback.
Biochemical simulations
Is the Subject Area "Biochemical simulations" applicable to this article?

Thanks for your feedback.
Protein interactions
Is the Subject Area "Protein interactions" applicable to this article?

Thanks for your feedback.
RNA analysis
Is the Subject Area "RNA analysis" applicable to this article?

Thanks for your feedback.