Branched-Chain Amino Acid Supplementation Reduces Oxidative Stress and Prolongs Survival in Rats with Advanced Liver Cirrhosis

Motoh Iwasa; Yoshinao Kobayashi; Rumi Mifuji-Moroka; Nagisa Hara; Hirohide Miyachi; Ryosuke Sugimoto; Hideaki Tanaka; Naoki Fujita; Esteban C. Gabazza; Yoshiyuki Takei

doi:10.1371/journal.pone.0070309

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Peer-reviewed

Research Article

Branched-Chain Amino Acid Supplementation Reduces Oxidative Stress and Prolongs Survival in Rats with Advanced Liver Cirrhosis

Motoh Iwasa ,

Contributed equally to this work with: Motoh Iwasa, Yoshinao Kobayashi

* E-mail: motoh@clin.medic.mie-u.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Yoshinao Kobayashi ,

Contributed equally to this work with: Motoh Iwasa, Yoshinao Kobayashi

Affiliations Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan, Center for Physical and Mental Health, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Rumi Mifuji-Moroka,

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Nagisa Hara,

Affiliation Division of Dietary Service, Mie University School Hospital, Tsu, Japan
⨯
Hirohide Miyachi,

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Ryosuke Sugimoto,

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Hideaki Tanaka,

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Naoki Fujita,

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Esteban C. Gabazza,

Affiliation Department of Immunology, Mie University Graduate School of Medicine, Tsu, Japan
⨯
Yoshiyuki Takei

Affiliation Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
⨯

Branched-Chain Amino Acid Supplementation Reduces Oxidative Stress and Prolongs Survival in Rats with Advanced Liver Cirrhosis

Motoh Iwasa,
Yoshinao Kobayashi,
Rumi Mifuji-Moroka,
Nagisa Hara,
Hirohide Miyachi,
Ryosuke Sugimoto,
Hideaki Tanaka,
Naoki Fujita,
Esteban C. Gabazza,
Yoshiyuki Takei

Published: July 25, 2013
https://doi.org/10.1371/journal.pone.0070309

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