MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts

Antonio Curcio; Daniele Torella; Claudio Iaconetti; Eugenia Pasceri; Jolanda Sabatino; Sabato Sorrentino; Salvatore Giampà; Mariella Micieli; Alberto Polimeni; Beverley J. Henning; Angelo Leone; Daniele Catalucci; Georgina M. Ellison; Gianluigi Condorelli; Ciro Indolfi

doi:10.1371/journal.pone.0070158

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Peer-reviewed

Research Article

MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts

Antonio Curcio,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Daniele Torella,

Affiliations Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy, Biostem Unit, RISES, Liverpool John Moores University, Liverpool, United Kingdom
⨯
Claudio Iaconetti,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Eugenia Pasceri,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Jolanda Sabatino,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Sabato Sorrentino,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Salvatore Giampà,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Mariella Micieli,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Alberto Polimeni,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Beverley J. Henning,

Affiliation Biostem Unit, RISES, Liverpool John Moores University, Liverpool, United Kingdom
⨯
Angelo Leone,

Affiliation Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
⨯
Daniele Catalucci,

Affiliation Humanitas Clinical and Research Center, Rozzano, Milan, and National Research Council, Italy
⨯
Georgina M. Ellison,

Affiliations Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy, Biostem Unit, RISES, Liverpool John Moores University, Liverpool, United Kingdom
⨯
Gianluigi Condorelli,

Affiliation Humanitas Clinical and Research Center, Rozzano, Milan, and National Research Council, Italy
⨯
Ciro Indolfi

* E-mail: indolfi@unicz.it

Affiliations Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy, URT - National Research Council, University Magna Graecia, Catanzaro, Italy
⨯

MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts

Antonio Curcio,
Daniele Torella,
Claudio Iaconetti,
Eugenia Pasceri,
Jolanda Sabatino,
Sabato Sorrentino,
Salvatore Giampà,
Mariella Micieli,
Alberto Polimeni,
Beverley J. Henning

Published: July 26, 2013
https://doi.org/10.1371/journal.pone.0070158

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