Enzymatic Assays for the Diagnosis of Bradykinin-Dependent Angioedema

Federica Defendi; Delphine Charignon; Arije Ghannam; Remi Baroso; Françoise Csopaki; Marion Allegret-Cadet; Denise Ponard; Bertrand Favier; Sven Cichon; Brigitte Nicolie; Olivier Fain; Ludovic Martin; Christian Drouet; on behalf of the National Reference Centre for Angioedema CREAK

doi:10.1371/journal.pone.0070140

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Peer-reviewed

Research Article

Enzymatic Assays for the Diagnosis of Bradykinin-Dependent Angioedema

Federica Defendi ,

* E-mail: FDefendi@chu-grenoble.fr

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
Delphine Charignon,

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
Arije Ghannam,

Affiliation Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
Remi Baroso,

Affiliation Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
Françoise Csopaki,

Affiliation Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France
⨯
Marion Allegret-Cadet,

Affiliation Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France
⨯
Denise Ponard,

Affiliation Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France
⨯
Bertrand Favier,

Affiliation Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
Sven Cichon,

Affiliations Universität Bonn, Institut für Humangenetik, Bonn, Germany, Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
⨯
Brigitte Nicolie,

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, CHU Angers, Département d’Allergologie, Angers, France
⨯
Olivier Fain,

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, Université Paris XIII, AP-HP, Hôpital Jean Verdier, Médecine Interne, Bondy, France
⨯
Ludovic Martin ,

Contributed equally to this work with: Ludovic Martin, Christian Drouet

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, Université L’UNAM, Hôpital d’Angers, Département de Dermatologie, Angers, France
⨯
Christian Drouet ,

Contributed equally to this work with: Ludovic Martin, Christian Drouet

Affiliations Centre de Référence des Angioedèmes à Kinines, CREAK, Grenoble, France, Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble, France
⨯
on behalf of the National Reference Centre for Angioedema CREAK

Enzymatic Assays for the Diagnosis of Bradykinin-Dependent Angioedema

Federica Defendi,
Delphine Charignon,
Arije Ghannam,
Remi Baroso,
Françoise Csopaki,
Marion Allegret-Cadet,
Denise Ponard,
Bertrand Favier,
Sven Cichon,
Brigitte Nicolie

Published: August 5, 2013
https://doi.org/10.1371/journal.pone.0070140

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