Protective Efficacy of VP1-Specific Neutralizing Antibody Associated with a Reduction of Viral Load and Pro-Inflammatory Cytokines in Human SCARB2-Transgenic Mice

Hsuen-Wen Chang; Yi-Wen Lin; Hui-Min Ho; Min-Han Lin; Chia-Chyi Liu; Hsiao-Yun Shao; Pele Chong; Charles Sia; Yen-Hung Chow

doi:10.1371/journal.pone.0069858

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Open Access

Peer-reviewed

Research Article

Protective Efficacy of VP1-Specific Neutralizing Antibody Associated with a Reduction of Viral Load and Pro-Inflammatory Cytokines in Human SCARB2-Transgenic Mice

Hsuen-Wen Chang,

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯
Yi-Wen Lin,

Affiliations National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan, Graduate Program of Biotechnology in Medicine, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan
⨯
Hui-Min Ho,

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯
Min-Han Lin,

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯
Chia-Chyi Liu,

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯
Hsiao-Yun Shao,

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯
Pele Chong,

Affiliations National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan
⨯
Charles Sia ,

* E-mail: siady@nhri.org.tw (CS); choeyenh@nhri.org.tw (YHC)

Affiliations National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan
⨯
Yen-Hung Chow

* E-mail: siady@nhri.org.tw (CS); choeyenh@nhri.org.tw (YHC)

Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan town, Miaoli County, Taiwan
⨯

Protective Efficacy of VP1-Specific Neutralizing Antibody Associated with a Reduction of Viral Load and Pro-Inflammatory Cytokines in Human SCARB2-Transgenic Mice

Hsuen-Wen Chang,
Yi-Wen Lin,
Hui-Min Ho,
Min-Han Lin,
Chia-Chyi Liu,
Hsiao-Yun Shao,
Pele Chong,
Charles Sia,
Yen-Hung Chow

Published: July 30, 2013
https://doi.org/10.1371/journal.pone.0069858

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