The Interactions in the Carboxyl Terminus of Human 4-Hydroxyphenylpyruvate Dioxygenase Are Critical to Mediate the Conformation of the Final Helix and the Tail to Shield the Active Site for Catalysis

• Jang-Foung Lin ,

  Contributed equally to this work with: Jang-Foung Lin, Yung-Lin Sheih

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Yung-Lin Sheih ,

  Contributed equally to this work with: Jang-Foung Lin, Yung-Lin Sheih

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Tsu-Chung Chang,

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Ni-Yuan Chang,

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Chiung-Wen Chang,

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Chia-Pei Shen,

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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• Hwei-Jen Lee

  * E-mail: hjlee@mail.ndmctsgh.edu.tw

  Affiliation Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan

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