Deep Sequencing Analysis of HCV NS3 Resistance-Associated Variants and Mutation Linkage in Liver Transplant Recipients

Mariana E. Kirst; Eric C. Li; Cindy X. Wang; Hui-Jia Dong; Chen Liu; Michael W. Fried; David R. Nelson; Gary P. Wang

doi:10.1371/journal.pone.0069698

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Open Access

Peer-reviewed

Research Article

Deep Sequencing Analysis of HCV NS3 Resistance-Associated Variants and Mutation Linkage in Liver Transplant Recipients

Mariana E. Kirst,

Affiliation College of Medicine, Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Eric C. Li,

Affiliation College of Medicine, Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Cindy X. Wang,

Affiliation College of Medicine, Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Hui-Jia Dong,

Affiliation College of Medicine, Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Chen Liu,

Affiliation College of Medicine, Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Michael W. Fried,

Affiliation Department of Medicine, Division of Gastroenterology, University of North Carolina Chapel Hill, North Carolina, United States of America
⨯
David R. Nelson,

Affiliation College of Medicine, Department of Medicine, Division of Gastroenterology, University of Florida, Gainesville, Florida, United States of America
⨯
Gary P. Wang

* E-mail: gary.wang@medicine.ufl.edu

Affiliation College of Medicine, Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, Florida, United States of America
⨯

Deep Sequencing Analysis of HCV NS3 Resistance-Associated Variants and Mutation Linkage in Liver Transplant Recipients

Mariana E. Kirst,
Eric C. Li,
Cindy X. Wang,
Hui-Jia Dong,
Chen Liu,
Michael W. Fried,
David R. Nelson,
Gary P. Wang

Published: July 29, 2013
https://doi.org/10.1371/journal.pone.0069698

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Liver transplantation
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Protease inhibitor therapy
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Antiviral therapy
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RNA sequencing
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Hepatitis C virus
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Linkage analysis
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Mutation detection
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Protease inhibitors
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