LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity

Christopher J. Greene; Chrystal M. Chadwick; Lorrie M. Mandell; John C. Hu; Joanne M. O’Hara; Robert N. Brey III; Nicholas J. Mantis; Terry D. Connell

doi:10.1371/journal.pone.0069678

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Research Article

LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity

Christopher J. Greene,

Affiliations The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America, The Department of Microbiology and Immunology, The University at Buffalo, Buffalo, New York, United States of America
⨯
Chrystal M. Chadwick,

Affiliation Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
⨯
Lorrie M. Mandell,

Affiliations The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America, The Department of Microbiology and Immunology, The University at Buffalo, Buffalo, New York, United States of America
⨯
John C. Hu,

Affiliations The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America, The Department of Microbiology and Immunology, The University at Buffalo, Buffalo, New York, United States of America
⨯
Joanne M. O’Hara,

Affiliations Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, The Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America
⨯
Robert N. Brey III,

Affiliation Soligenix, Inc., Princeton, New Jersey, United States of America
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Nicholas J. Mantis ,

* E-mail: connell@buffalo.edu (TDC); nmantis@wadsworth.org (NJM)

Affiliations Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, The Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America
⨯
Terry D. Connell

* E-mail: connell@buffalo.edu (TDC); nmantis@wadsworth.org (NJM)

Affiliations The Witebsky Center for Microbial Pathogenesis and Immunology, The University at Buffalo, Buffalo, New York, United States of America, The Department of Microbiology and Immunology, The University at Buffalo, Buffalo, New York, United States of America
⨯

LT-IIb(T13I), a Non-Toxic Type II Heat-Labile Enterotoxin, Augments the Capacity of a Ricin Toxin Subunit Vaccine to Evoke Neutralizing Antibodies and Protective Immunity

Christopher J. Greene,
Chrystal M. Chadwick,
Lorrie M. Mandell,
John C. Hu,
Joanne M. O’Hara,
Robert N. Brey III,
Nicholas J. Mantis,
Terry D. Connell

Published: August 2, 2013
https://doi.org/10.1371/journal.pone.0069678

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