4-1BB Signaling Activates the T Cell Factor 1 Effector/β-Catenin Pathway with Delayed Kinetics via ERK Signaling and Delayed PI3K/AKT Activation to Promote the Proliferation of CD8+ T Cells

Open Access

Peer-reviewed

Research Article

4-1BB Signaling Activates the T Cell Factor 1 Effector/β-Catenin Pathway with Delayed Kinetics via ERK Signaling and Delayed PI3K/AKT Activation to Promote the Proliferation of CD8⁺ T Cells

Do Y. Lee ,

Contributed equally to this work with: Do Y. Lee, Beom K. Choi

Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Beom K. Choi ,

Contributed equally to this work with: Do Y. Lee, Beom K. Choi

Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Don G. Lee,

Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Young H. Kim,

Affiliation Immune Cell Production Unit, Program for Immunotherapeutic Research, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Chang H. Kim,

Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Seung J. Lee,

Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea
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Byoung S. Kwon

* E-mail: bskwon@ncc.re.kr

Current address: Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi-do, Korea

Affiliations Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi-do, Korea, Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
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T cells
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Cytotoxic T cells
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ERK signaling cascade
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Signal inhibition
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Wnt signaling cascade
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Transcription factors
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Cell signaling
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T cell receptors
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