Intelligently Targeted Drug Delivery and Enhanced Antitumor Effect by Gelatinase-Responsive Nanoparticles

Rutian Li; Wei Wu; Qin Liu; Puyuan Wu; Li Xie; Zhenshu Zhu; Mi Yang; Xiaoping Qian; Yin Ding; Lixia Yu; Xiqun Jiang; Wenxian Guan; Baorui Liu

doi:10.1371/journal.pone.0069643

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Open Access

Peer-reviewed

Research Article

Intelligently Targeted Drug Delivery and Enhanced Antitumor Effect by Gelatinase-Responsive Nanoparticles

Rutian Li,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Wei Wu,

Affiliation Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P.R. China
⨯
Qin Liu,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Puyuan Wu,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Li Xie,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Zhenshu Zhu,

Affiliation Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, P.R. China
⨯
Mi Yang,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Xiaoping Qian,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Yin Ding,

Affiliation Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P.R. China
⨯
Lixia Yu,

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯
Xiqun Jiang,

Affiliation Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P.R. China
⨯
Wenxian Guan ,

* E-mail: Guanwenxian@163.com (WG); Baoruiliu@nju.edu.cn (BL)

Affiliation Department of General Surgery, Drum-Tower Hospital, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Baorui Liu

* E-mail: Guanwenxian@163.com (WG); Baoruiliu@nju.edu.cn (BL)

Affiliation The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, P.R. China
⨯

Intelligently Targeted Drug Delivery and Enhanced Antitumor Effect by Gelatinase-Responsive Nanoparticles

Rutian Li,
Wei Wu,
Qin Liu,
Puyuan Wu,
Li Xie,
Zhenshu Zhu,
Mi Yang,
Xiaoping Qian,
Yin Ding,
Lixia Yu

Published: July 30, 2013
https://doi.org/10.1371/journal.pone.0069643

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