A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics

Tsin W. Yeo; Daniel A. Lampah; Indri Rooslamiati; Retno Gitawati; Emiliana Tjitra; Enny Kenangalem; Ric N. Price; Stephen B. Duffull; Nicholas M. Anstey

doi:10.1371/journal.pone.0069587

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Open Access

Peer-reviewed

Research Article

A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics

Tsin W. Yeo ,

* E-mail: tsin.yeo@menzies.edu.au

Affiliations Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
⨯
Daniel A. Lampah,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Indri Rooslamiati,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Retno Gitawati,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Emiliana Tjitra,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Enny Kenangalem,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Ric N. Price,

Affiliations Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Stephen B. Duffull,

Affiliation School of Pharmacy, University of Otago, Dunedin, New Zealand
⨯
Nicholas M. Anstey

Affiliations Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
⨯

A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics

Tsin W. Yeo,
Daniel A. Lampah,
Indri Rooslamiati,
Retno Gitawati,
Emiliana Tjitra,
Enny Kenangalem,
Ric N. Price,
Stephen B. Duffull,
Nicholas M. Anstey

Published: July 29, 2013
https://doi.org/10.1371/journal.pone.0069587

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