Inhibition of Inducible Heat Shock Protein-70 (Hsp72) Enhances Bortezomib-Induced Cell Death in Human Bladder Cancer Cells

Wei Qi; Matthew C. White; Woonyoung Choi; Charles Guo; Colin Dinney; David J. McConkey; Arlene Siefker-Radtke

doi:10.1371/journal.pone.0069509

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Peer-reviewed

Research Article

Inhibition of Inducible Heat Shock Protein-70 (Hsp72) Enhances Bortezomib-Induced Cell Death in Human Bladder Cancer Cells

Wei Qi ,

Contributed equally to this work with: Wei Qi, Matthew C. White

Affiliation Department of Urology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯
Matthew C. White ,

Contributed equally to this work with: Wei Qi, Matthew C. White

Affiliations Department of Urology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America, Department of Cancer Biology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America, The Graduate School of Biomedical Sciences, University of Texas Health Sciences Center, Houston, Texas, United States of America
⨯
Woonyoung Choi,

Affiliation Department of Cancer Biology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯
Charles Guo,

Affiliation Department of Pathology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯
Colin Dinney,

Affiliation Department of Cancer Biology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯
David J. McConkey ,

* E-mail: dmcconke@mdanderson.org (DM); asiefker@mdanderson.org (ASR)

Affiliations Department of Urology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America, Department of Cancer Biology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯
Arlene Siefker-Radtke

* E-mail: dmcconke@mdanderson.org (DM); asiefker@mdanderson.org (ASR)

Affiliation Department of Genitourinary Medical Oncology, U. T. M. D. Anderson Cancer Center Houston, Texas, United States of America
⨯

Inhibition of Inducible Heat Shock Protein-70 (Hsp72) Enhances Bortezomib-Induced Cell Death in Human Bladder Cancer Cells

Wei Qi,
Matthew C. White,
Woonyoung Choi,
Charles Guo,
Colin Dinney,
David J. McConkey,
Arlene Siefker-Radtke

Published: July 18, 2013
https://doi.org/10.1371/journal.pone.0069509

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Bladder cancer
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DNA methylation
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Gene expression
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Cell death
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Malignant tumors
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Heat shock response
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Polymerase chain reaction
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