Nonlinear Mixed-Effects Modelling of In Vitro Drug Susceptibility and Molecular Correlates of Multidrug Resistant Plasmodium falciparum

Julie A. Simpson; Kris M. Jamsen; Tim J. C. Anderson; Sophie Zaloumis; Shalini Nair; Charles Woodrow; Nicholas J. White; Francois Nosten; Ric N. Price

doi:10.1371/journal.pone.0069505

Loading metrics

Open Access

Peer-reviewed

Research Article

Nonlinear Mixed-Effects Modelling of In Vitro Drug Susceptibility and Molecular Correlates of Multidrug Resistant Plasmodium falciparum

Julie A. Simpson ,

* E-mail: julieas@unimelb.edu.au

Affiliation Centre for Molecular, Environmental, Genetic & Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
⨯
Kris M. Jamsen,

Affiliation Centre for Molecular, Environmental, Genetic & Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
⨯
Tim J. C. Anderson,

Affiliation Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Sophie Zaloumis,

Affiliation Centre for Molecular, Environmental, Genetic & Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
⨯
Shalini Nair,

Affiliation Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Charles Woodrow,

Affiliations Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, WorldWide Antimalarial Resistance Network (WWARN), Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Nicholas J. White,

Affiliations Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand
⨯
Francois Nosten,

Affiliations Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
⨯
Ric N. Price

Affiliations Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, WorldWide Antimalarial Resistance Network (WWARN), Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
⨯

Nonlinear Mixed-Effects Modelling of In Vitro Drug Susceptibility and Molecular Correlates of Multidrug Resistant Plasmodium falciparum

Julie A. Simpson,
Kris M. Jamsen,
Tim J. C. Anderson,
Sophie Zaloumis,
Shalini Nair,
Charles Woodrow,
Nicholas J. White,
Francois Nosten,
Ric N. Price

Published: July 24, 2013
https://doi.org/10.1371/journal.pone.0069505

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mefloquine
Is the Subject Area "Mefloquine" applicable to this article?

Thanks for your feedback.
Artesunate
Is the Subject Area "Artesunate" applicable to this article?

Thanks for your feedback.
Chloroquine
Is the Subject Area "Chloroquine" applicable to this article?

Thanks for your feedback.
Antimalarials
Is the Subject Area "Antimalarials" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.
Statistical distributions
Is the Subject Area "Statistical distributions" applicable to this article?

Thanks for your feedback.
Variant genotypes
Is the Subject Area "Variant genotypes" applicable to this article?

Thanks for your feedback.