Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins

Andrés E. Ibañez; Paola Smaldini; Lorena M. Coria; María V. Delpino; Lucila G. G. Pacífico; Sergio C. Oliveira; Gabriela S. Risso; Karina A. Pasquevich; Carlos Alberto Fossati; Guillermo H. Giambartolomei; Guillermo H. Docena; Juliana Cassataro

doi:10.1371/journal.pone.0069438

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Peer-reviewed

Research Article

Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins

Andrés E. Ibañez,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Paola Smaldini,

Affiliation Laboratorio de Investigaciones del Sistema Inmune (LISIN), Facultad de Ciencias Exactas, Universidad Nacional de la Plata, Buenos Aires, Argentina
⨯
Lorena M. Coria,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
María V. Delpino,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Lucila G. G. Pacífico,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯
Sergio C. Oliveira,

Affiliation Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯
Gabriela S. Risso,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Karina A. Pasquevich,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Carlos Alberto Fossati,

Affiliations Laboratorio de Investigaciones del Sistema Inmune (LISIN), Facultad de Ciencias Exactas, Universidad Nacional de la Plata, Buenos Aires, Argentina, Instituto de Estudios de la Inmunidad Humoral (IDEHU-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Guillermo H. Giambartolomei,

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯
Guillermo H. Docena,

Affiliation Laboratorio de Investigaciones del Sistema Inmune (LISIN), Facultad de Ciencias Exactas, Universidad Nacional de la Plata, Buenos Aires, Argentina
⨯
Juliana Cassataro

* E-mail: jucassataro@yahoo.com.ar

Affiliation Laboratorio de Inmunogenética, INIGEM-CONICET, Hospital de Clínicas “José de San Martín”, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
⨯

Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins

Andrés E. Ibañez,
Paola Smaldini,
Lorena M. Coria,
María V. Delpino,
Lucila G. G. Pacífico,
Sergio C. Oliveira,
Gabriela S. Risso,
Karina A. Pasquevich,
Carlos Alberto Fossati,
Guillermo H. Giambartolomei

Published: July 5, 2013
https://doi.org/10.1371/journal.pone.0069438

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