4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

• Atsushi Ishikado ,

  Contributed equally to this work with: Atsushi Ishikado, Katsutaro Morino

  Affiliations Department of Medicine, Shiga University of Medical Science, Shiga, Japan, Research & Development Department, Sunstar Inc., Osaka, Japan

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• Katsutaro Morino ,

  Contributed equally to this work with: Atsushi Ishikado, Katsutaro Morino

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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• Yoshihiko Nishio ,

  * E-mail: ynishio@m3.kufm.kagoshima-u.ac.jp

  Affiliation Department of Diabetes, Metabolism and Endocrinology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

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• Fumiyuki Nakagawa,

  Affiliations Department of Medicine, Shiga University of Medical Science, Shiga, Japan, Osaka Laboratory, JCL Bioassay Corporation, Osaka, Japan

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• Atsushi Mukose,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

  ⨯
• Yoko Sono,

  Affiliation Research & Development Department, Sunstar Inc., Osaka, Japan

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• Nagisa Yoshioka,

  Affiliation Osaka Laboratory, JCL Bioassay Corporation, Osaka, Japan

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• Keiko Kondo,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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• Osamu Sekine,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

  ⨯
• Takeshi Yoshizaki,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

  ⨯
• Satoshi Ugi,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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• Takashi Uzu,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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• Hiromichi Kawai,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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• Taketoshi Makino,

  Affiliation Research & Development Department, Sunstar Inc., Osaka, Japan

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• Tomio Okamura,

  Affiliation Department of Pharmacology, Shiga University of Medical Science, Shiga, Japan

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• Masayuki Yamamoto,

  Affiliation Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Miyagi, Japan

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• Atsunori Kashiwagi,

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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•  [ ... ],
• Hiroshi Maegawa

  Affiliation Department of Medicine, Shiga University of Medical Science, Shiga, Japan

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