Transport Inhibition of Digoxin Using Several Common P-gp Expressing Cell Lines Is Not Necessarily Reporting Only on Inhibitor Binding to P-gp

Annie Albin Lumen; Libin Li; Jiben Li; Zeba Ahmed; Zhou Meng; Albert Owen; Harma Ellens; Ismael J. Hidalgo; Joe Bentz

doi:10.1371/journal.pone.0069394

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Research Article

Transport Inhibition of Digoxin Using Several Common P-gp Expressing Cell Lines Is Not Necessarily Reporting Only on Inhibitor Binding to P-gp

Annie Albin Lumen ,

Current address: National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas, United States of America

¶AAL and LL are joint first authors on this work.

Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Libin Li ,

¶AAL and LL are joint first authors on this work.

Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
⨯
Jiben Li,

Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
⨯
Zeba Ahmed,

Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Zhou Meng,

Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Albert Owen,

Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
⨯
Harma Ellens ,

* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)

Affiliation Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Ismael J. Hidalgo ,

* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)

Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
⨯
Joe Bentz

* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)

Affiliation Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America
⨯

Transport Inhibition of Digoxin Using Several Common P-gp Expressing Cell Lines Is Not Necessarily Reporting Only on Inhibitor Binding to P-gp

Annie Albin Lumen,
Libin Li,
Jiben Li,
Zeba Ahmed,
Zhou Meng,
Albert Owen,
Harma Ellens,
Ismael J. Hidalgo,
Joe Bentz

Published: August 16, 2013
https://doi.org/10.1371/journal.pone.0069394

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