Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

Aika Nojima; Masakatsu Yamashita; Yohko Yoshida; Ippei Shimizu; Harumi Ichimiya; Naomi Kamimura; Yoshio Kobayashi; Shigeo Ohta; Naoaki Ishii; Tohru Minamino

doi:10.1371/journal.pone.0069178

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Open Access

Peer-reviewed

Research Article

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

Aika Nojima,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masakatsu Yamashita,

Affiliation Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
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Yohko Yoshida,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Ippei Shimizu,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Harumi Ichimiya,

Affiliation Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara-ku, Kawasaki, Kanagawa, Japan
⨯
Naomi Kamimura,

Affiliation Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara-ku, Kawasaki, Kanagawa, Japan
⨯
Yoshio Kobayashi,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Shigeo Ohta,

Affiliation Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara-ku, Kawasaki, Kanagawa, Japan
⨯
Naoaki Ishii,

Affiliation Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Japan
⨯
Tohru Minamino

* E-mail: t_minamino@yahoo.co.jp

Affiliations Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
⨯

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

Aika Nojima,
Masakatsu Yamashita,
Yohko Yoshida,
Ippei Shimizu,
Harumi Ichimiya,
Naomi Kamimura,
Yoshio Kobayashi,
Shigeo Ohta,
Naoaki Ishii,
Tohru Minamino

Published: July 30, 2013
https://doi.org/10.1371/journal.pone.0069178

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