Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells

Shi-Jiang Fei; Xu-Chao Zhang; Song Dong; Hua Cheng; Yi-Fang Zhang; Ling Huang; Hai-Yu Zhou; Zhi Xie; Zhi-Hong Chen; Yi-Long Wu

doi:10.1371/journal.pone.0069104

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Open Access

Peer-reviewed

Research Article

Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells

Shi-Jiang Fei,

Affiliations Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China, Graduate School of Southern Medical University, Guangzhou, China
⨯
Xu-Chao Zhang,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Song Dong,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Hua Cheng,

Affiliation Thoracic oncology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China
⨯
Yi-Fang Zhang,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Ling Huang,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Hai-Yu Zhou,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Zhi Xie,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Zhi-Hong Chen,

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯
Yi-Long Wu

* E-mail: syylwu@live.cn

Affiliation Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
⨯

Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells

Shi-Jiang Fei,
Xu-Chao Zhang,
Song Dong,
Hua Cheng,
Yi-Fang Zhang,
Ling Huang,
Hai-Yu Zhou,
Zhi Xie,
Zhi-Hong Chen,
Yi-Long Wu

Published: July 16, 2013
https://doi.org/10.1371/journal.pone.0069104

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