Antisense-Oligonucleotide Mediated Exon Skipping in Activin-Receptor-Like Kinase 2: Inhibiting the Receptor That Is Overactive in Fibrodysplasia Ossificans Progressiva

SongTing Shi; Jie Cai; David J. J. de Gorter; Gonzalo Sanchez-Duffhues; Dwi U. Kemaladewi; Willem M. H. Hoogaars; Annemieke Aartsma-Rus; Peter A. C.  ’t Hoen; Peter ten Dijke

doi:10.1371/journal.pone.0069096

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Open Access

Peer-reviewed

Research Article

Antisense-Oligonucleotide Mediated Exon Skipping in Activin-Receptor-Like Kinase 2: Inhibiting the Receptor That Is Overactive in Fibrodysplasia Ossificans Progressiva

SongTing Shi ,

Contributed equally to this work with: SongTing Shi, Jie Cai

Affiliation Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jie Cai ,

Contributed equally to this work with: SongTing Shi, Jie Cai

Affiliation Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
David J. J. de Gorter,

Affiliations Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands, Institute for Molecular Cell Biology, University of Münster, Münster, Germany
⨯
Gonzalo Sanchez-Duffhues,

Affiliation Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Dwi U. Kemaladewi,

Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Willem M. H. Hoogaars,

Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Annemieke Aartsma-Rus,

Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Peter A. C. ’t Hoen,

Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Peter ten Dijke

* E-mail: P.ten_Dijke@lumc.nl

Affiliation Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯

Antisense-Oligonucleotide Mediated Exon Skipping in Activin-Receptor-Like Kinase 2: Inhibiting the Receptor That Is Overactive in Fibrodysplasia Ossificans Progressiva

SongTing Shi,
Jie Cai,
David J. J. de Gorter,
Gonzalo Sanchez-Duffhues,
Dwi U. Kemaladewi,
Willem M. H. Hoogaars,
Annemieke Aartsma-Rus,
Peter A. C. ’t Hoen,
Peter ten Dijke

Published: July 4, 2013
https://doi.org/10.1371/journal.pone.0069096

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