Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)

Jia-Xin Jiang; Karen J. Aitken; Chris Sotiropolous; Tyler Kirwan; Trupti Panchal; Nicole Zhang; Shuye Pu; Shoshana Wodak; Cornelia Tolg; Darius J. Bägli

doi:10.1371/journal.pone.0069089

Loading metrics

Open Access

Peer-reviewed

Research Article

Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)

Jia-Xin Jiang,

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
⨯
Karen J. Aitken ,

* E-mail: kjglennie@rogers.com

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Chris Sotiropolous,

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
⨯
Tyler Kirwan,

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Trupti Panchal,

Affiliation Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
⨯
Nicole Zhang,

Affiliation Department of Physiology, University of Toronto, Toronto, Ontario, Canada
⨯
Shuye Pu,

Affiliation Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Shoshana Wodak,

Affiliation Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Cornelia Tolg,

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Darius J. Bägli

Affiliations Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada, Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Sciences, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
⨯

Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)

Jia-Xin Jiang,
Karen J. Aitken,
Chris Sotiropolous,
Tyler Kirwan,
Trupti Panchal,
Nicole Zhang,
Shuye Pu,
Shoshana Wodak,
Cornelia Tolg,
Darius J. Bägli

Published: August 7, 2013
https://doi.org/10.1371/journal.pone.0069089

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Collagens
Is the Subject Area "Collagens" applicable to this article?

Thanks for your feedback.
Denaturation
Is the Subject Area "Denaturation" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Myosins
Is the Subject Area "Myosins" applicable to this article?

Thanks for your feedback.
Bladder
Is the Subject Area "Bladder" applicable to this article?

Thanks for your feedback.
Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Smooth muscle cells
Is the Subject Area "Smooth muscle cells" applicable to this article?

Thanks for your feedback.