NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Ahmad Jalili; Kirsten D. Mertz; Julia Romanov; Christine Wagner; Frank Kalthoff; Anton Stuetz; Gaurav Pathria; Melanie Gschaider; Georg Stingl; Stephan N. Wagner

doi:10.1371/journal.pone.0069064

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Open Access

Peer-reviewed

Research Article

NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Ahmad Jalili ,

* E-mail: ahmad.jalili@meduniwien.ac.at (AJ)

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Kirsten D. Mertz ,

* E-mail: ahmad.jalili@meduniwien.ac.at (AJ)

Affiliation Novartis Institutes for Biomedical Research, Vienna, Austria
⨯
Julia Romanov,

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Christine Wagner,

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Frank Kalthoff,

Affiliation Novartis Institutes for Biomedical Research, Vienna, Austria
⨯
Anton Stuetz,

Affiliation Novartis Institutes for Biomedical Research, Vienna, Austria
⨯
Gaurav Pathria,

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Melanie Gschaider,

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Georg Stingl,

Affiliation Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria
⨯
Stephan N. Wagner

Affiliations Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
⨯

NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Ahmad Jalili,
Kirsten D. Mertz,
Julia Romanov,
Christine Wagner,
Frank Kalthoff,
Anton Stuetz,
Gaurav Pathria,
Melanie Gschaider,
Georg Stingl,
Stephan N. Wagner

Published: July 30, 2013
https://doi.org/10.1371/journal.pone.0069064

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08 Sep 2013
18:44 GMT
Most Recent

Correction Posted by kmertz on 08 Sep 2013 at 18:44 GMT

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