The Dysfunction of CD4+CD25+ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy

Jin-ling Chen; Yi-yue Ge; Jie Zhang; Xiao-yan Qiu; Jing-fan Qiu; Jiang-ping Wu; Yong Wang

doi:10.1371/journal.pone.0069012

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Peer-reviewed

Research Article

The Dysfunction of CD4⁺CD25⁺ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy

Jin-ling Chen ,

Contributed equally to this work with: Jin-ling Chen, Yi-yue Ge

Affiliations Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Parasitology and Microbiology, School of Medicine, Nantong University, Nantong, Jiangsu, China
⨯
Yi-yue Ge ,

Contributed equally to this work with: Jin-ling Chen, Yi-yue Ge

Affiliations Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China, Institute of Pathogen Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China
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Jie Zhang,

Affiliation Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
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Xiao-yan Qiu,

Affiliation Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
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Jing-fan Qiu,

Affiliation Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
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Jiang-ping Wu,

Affiliation Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China
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Yong Wang

* E-mail: yongwsh@njmu.edu.cn

Affiliation Department of Pathogen Biology, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China
⨯

The Dysfunction of CD4⁺CD25⁺ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy

Jin-ling Chen,
Yi-yue Ge,
Jie Zhang,
Xiao-yan Qiu,
Jing-fan Qiu,
Jiang-ping Wu,
Yong Wang

Published: July 17, 2013
https://doi.org/10.1371/journal.pone.0069012

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Toxoplasma gondii
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Regulatory T cells
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Pregnancy
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T cells
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Intraperitoneal injections
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Termination of pregnancy
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