The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients

• Silke Metzger,

  Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, Rare Disease Center, University of Tuebingen, Tuebingen, Germany

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• Carolin Walter,

  Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, Rare Disease Center, University of Tuebingen, Tuebingen, Germany

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• Olaf Riess,

  Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, Rare Disease Center, University of Tuebingen, Tuebingen, Germany

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• Raymund A. C. Roos,

  Affiliation Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands

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• Jørgen E. Nielsen,

  Affiliations Memory Disorders Research Unit, Neurogenetics Clinic, Section 6702, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, Institute of Cellular and Molecular Medicine, Section of Neurogenetics, University of Copenhagen, The Panum Institute, Copenhagen, Denmark

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• David Craufurd,

  Affiliation Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust, St. Mary’s Hospital, Manchester, United Kingdom

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• REGISTRY Investigators of the European Huntington’s Disease Network ,

  ¶Membership of the REGISTRY Investigators of the European Huntington’s Disease Network is provided in the Acknowledgments

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• Huu Phuc Nguyen

  * E-mail: hoa.nguyen@med.uni-tuebingen.de

  Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, Rare Disease Center, University of Tuebingen, Tuebingen, Germany

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