Performance and Cost Efficiency of KRAS Mutation Testing for Metastatic Colorectal Cancer in Routine Diagnosis: The MOKAECM Study, a Nationwide Experience

• Hélène Blons ,

  Contributed equally to this work with: Hélène Blons, Etienne Rouleau, Nathanaël Charrier

  Affiliations UMR-S775, INSERM, Paris, France, Université Paris Descartes, Paris, France, Assistance Publique Hôpitaux de Paris Department of biology, Hôpital Européen Georges Pompidou, Paris, France

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• Etienne Rouleau ,

  Contributed equally to this work with: Hélène Blons, Etienne Rouleau, Nathanaël Charrier

  Affiliation Institut Curie, Paris, France

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• Nathanaël Charrier ,

  Contributed equally to this work with: Hélène Blons, Etienne Rouleau, Nathanaël Charrier

  Affiliation Assistance Publique Hôpitaux de Paris, Henri Mondor-Albert Chenevier Hospitals, Department of Public Health, Creteil; URCEco Ile de France, Paris, France

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• Gilles Chatellier,

  Affiliations Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, URC Paris, France, Université Paris Descartes, Paris, France

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• Jean-François Côté,

  Affiliation EA4340, Université de Versailles St Quentin en Yvelines; Assistance Publique Hôpitaux de Paris Hôpital Ambroise Paré, Department of Pathology; Boulogne-Billancourt, France

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• Jean-Christophe Pages,

  Affiliation INSERM U966, Université François Rabelais de Tours, Faculté de Médecine, Tours, France

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• Florence de Fraipont,

  Affiliation Grenoble University Hospital Department of biology, Grenoble, France

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• Jean-Christophe Boyer,

  Affiliation Nîmes University Hospital, Department of Biochemistry, Nîmes, France

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• Jean Philippe Merlio,

  Affiliation Bordeaux University Hospital Segalene Department of Tumor Biology, Pessac; Bordeaux University EA 2406, Bordeaux, France

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• Alain Morel,

  Affiliation Cancer Center Paul Papin; INSERM U892; University of Angers, Angers, France

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• Marie-Claude Gorisse,

  Affiliation Institut Jean Godinot, Reims, France

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• Patricia de Cremoux,

  Affiliation Assistance Publique Hôpitaux de Paris, Saint Louis Hospital, Molecular oncology unit, Department of biochemistry, Paris, France

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• Karen Leroy,

  Affiliation Assistance Publique Hôpitaux de Paris Department of pathology Henri Mondor Hospital, Creteil, France

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• Gérard Milano,

  Affiliation Institut Laccassagne, Nice, France

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• L’Houcine Ouafik,

  Affiliation Aix-Marseille Université, Inserm-CRO2 UMR911, AP-HM, CHU Nord, Service de Transfert d’Oncologie Biologique, Marseille, France

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• Jean-Louis Merlin,

  Affiliation Centre Alexis Vautrin, Vandoeuvre-les-Nancy, France

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• Delphine Le Corre,

  Affiliation UMR-S775, INSERM, Paris, France

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• Pascaline Aucouturier,

  Affiliation Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, URC Paris, France

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• Jean-Christophe Sabourin,

  Affiliation Rouen University Hospital Department of surgical and molecular pathology; Inserm U1079, Rouen, France

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• Frédérique Nowak,

  Affiliation INCa Institut National du Cancer, Boulogne-Billancourt, France

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• Thierry Frebourg ,

  ¶These authors also contributed equally to this work.

  Affiliation Rouen University Hospital Department of Genetics, Inserm U614, Rouen, France

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• Jean-François Emile ,

  ¶These authors also contributed equally to this work.

  Affiliation EA4340, Université de Versailles St Quentin en Yvelines; Assistance Publique Hôpitaux de Paris Hôpital Ambroise Paré, Department of Pathology; Boulogne-Billancourt, France

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• Isabelle Durand-Zaleski ,

  ¶These authors also contributed equally to this work.

  Affiliation Assistance Publique Hôpitaux de Paris, Henri Mondor-Albert Chenevier Hospitals, Department of Public Health, Creteil; URCEco Ile de France, Paris, France

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• Pierre Laurent-Puig ,

  * E-mail: pierre.laurent-puig@parisdescartes.fr

  ¶These authors also contributed equally to this work.

  Affiliations UMR-S775, INSERM, Paris, France, Université Paris Descartes, Paris, France, Assistance Publique Hôpitaux de Paris Department of biology, Hôpital Européen Georges Pompidou, Paris, France

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•  [ ... ],
• on behalf of the MOKAECM collaborative group

  ¶† Membership of the MOKAECM collaborative group is provided in the Acknowledgments.

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