Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

Crystal M. Darby; Helgi I. Ingólfsson; Xiuju Jiang; Chun Shen; Mingna Sun; Nan Zhao; Kristin Burns; Gang Liu; Sabine Ehrt; J. David Warren; Olaf S. Anderson; Steven J. Brickner; Carl Nathan

doi:10.1371/journal.pone.0068942

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Open Access

Peer-reviewed

Research Article

Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

Crystal M. Darby,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Helgi I. Ingólfsson,

Affiliation Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America
⨯
Xiuju Jiang,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Chun Shen,

Affiliation Milstein Chemistry Core Facility, Weill Cornell Medical College, New York, New York, United States of America
⨯
Mingna Sun,

Affiliation Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Nan Zhao,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Kristin Burns,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Gang Liu,

Affiliations Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China, Tsinghua-Peking Center for Life Sciences and Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China
⨯
Sabine Ehrt,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
J. David Warren,

Affiliations Milstein Chemistry Core Facility, Weill Cornell Medical College, New York, New York, United States of America, Department of Biochemistry, Weill Cornell Medical College, New York, New York, United States of America
⨯
Olaf S. Anderson,

Affiliation Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America
⨯
Steven J. Brickner,

Affiliation SJ Brickner Consulting, LLC, Ledyard, Connecticut, United States of America
⨯
Carl Nathan

* E-mail: cnathan@med.cornell.edu

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯

Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

Crystal M. Darby,
Helgi I. Ingólfsson,
Xiuju Jiang,
Chun Shen,
Mingna Sun,
Nan Zhao,
Kristin Burns,
Gang Liu,
Sabine Ehrt,
J. David Warren

Published: July 30, 2013
https://doi.org/10.1371/journal.pone.0068942

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Membrane potential
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Homeostasis
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