Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

Yuan-peng Xia; Quan-wei He; Ya-nan Li; Sheng-cai Chen; Ming Huang; Yong Wang; Yuan Gao; Yan Huang; Meng-die Wang; Ling Mao; Bo Hu

doi:10.1371/journal.pone.0068891

Loading metrics

Open Access

Peer-reviewed

Research Article

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

Yuan-peng Xia ,

Contributed equally to this work with: Yuan-peng Xia, Quan-wei He, Ya-nan Li

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Quan-wei He ,

Contributed equally to this work with: Yuan-peng Xia, Quan-wei He, Ya-nan Li

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ya-nan Li ,

Contributed equally to this work with: Yuan-peng Xia, Quan-wei He, Ya-nan Li

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Sheng-cai Chen,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ming Huang,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yong Wang,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yuan Gao,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yan Huang,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Meng-die Wang,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ling Mao,

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Bo Hu

* E-mail: hubo@mail.hust.edu.cn

Affiliation Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

Yuan-peng Xia,
Quan-wei He,
Ya-nan Li,
Sheng-cai Chen,
Ming Huang,
Yong Wang,
Yuan Gao,
Yan Huang,
Meng-die Wang,
Ling Mao

Published: July 23, 2013
https://doi.org/10.1371/journal.pone.0068891

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Edema
Is the Subject Area "Edema" applicable to this article?

Thanks for your feedback.
Cerebral ischemia
Is the Subject Area "Cerebral ischemia" applicable to this article?

Thanks for your feedback.
Blood-brain barrier
Is the Subject Area "Blood-brain barrier" applicable to this article?

Thanks for your feedback.
Reverse transcriptase-polymerase chain reaction
Is the Subject Area "Reverse transcriptase-polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Tight junctions
Is the Subject Area "Tight junctions" applicable to this article?

Thanks for your feedback.
Blood-brain barrier permeability assay
Is the Subject Area "Blood-brain barrier permeability assay" applicable to this article?

Thanks for your feedback.
Hedgehog signaling
Is the Subject Area "Hedgehog signaling" applicable to this article?

Thanks for your feedback.