Unique Gene Expression and MR T2 Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease

Christine Breynaert; Tom Dresselaers; Clémentine Perrier; Ingrid Arijs; Jonathan Cremer; Leentje Van Lommel; Kristel Van Steen; Marc Ferrante; Frans Schuit; Séverine Vermeire; Paul Rutgeerts; Uwe Himmelreich; Jan L. Ceuppens; Karel Geboes; Gert Van Assche

doi:10.1371/journal.pone.0068876

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Open Access

Peer-reviewed

Research Article

Unique Gene Expression and MR T₂ Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease

Christine Breynaert,

Affiliations Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium, Laboratory of Clinical immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
⨯
Tom Dresselaers,

Affiliation Biomedical MRI/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
⨯
Clémentine Perrier,

Affiliations Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium, Laboratory of Clinical immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
⨯
Ingrid Arijs,

Affiliations Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium, Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Jonathan Cremer,

Affiliations Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium, Laboratory of Clinical immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
⨯
Leentje Van Lommel,

Affiliation Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Kristel Van Steen,

Affiliation Montefiore Institute, System and Modeling Unit, University of Liège, Liège, Belgium
⨯
Marc Ferrante,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Frans Schuit,

Affiliation Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Séverine Vermeire,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Paul Rutgeerts,

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
⨯
Uwe Himmelreich,

Affiliation Biomedical MRI/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
⨯
Jan L. Ceuppens,

Affiliation Laboratory of Clinical immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
⨯
Karel Geboes,

Affiliation Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
⨯
Gert Van Assche

* E-mail: Gert.Vanassche@uzleuven.be

Affiliation Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
⨯

Unique Gene Expression and MR T₂ Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease

Christine Breynaert,
Tom Dresselaers,
Clémentine Perrier,
Ingrid Arijs,
Jonathan Cremer,
Leentje Van Lommel,
Kristel Van Steen,
Marc Ferrante,
Frans Schuit,
Séverine Vermeire

Published: July 23, 2013
https://doi.org/10.1371/journal.pone.0068876

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