Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

Open Access

Peer-reviewed

Research Article

Nicholas A. Cilfone,

Affiliation Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
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Cory R. Perry,

Affiliation Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Denise E. Kirschner ,

* E-mail: kirschne@umich.edu (DEK); linderma@umich.edu (JJL)

Affiliation Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Jennifer J. Linderman

* E-mail: kirschne@umich.edu (DEK); linderma@umich.edu (JJL)

Affiliation Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
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Granulomas
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Mycobacterium tuberculosis
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Apoptosis
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Macrophages
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Immune cells
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Immune response
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T cells
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Cytokines
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