Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

John Timothy Caldwell; Holly Edwards; Alan A. Dombkowski; Steven A. Buck; Larry H. Matherly; Yubin Ge; Jeffrey W. Taub

doi:10.1371/journal.pone.0068601

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Peer-reviewed

Research Article

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

John Timothy Caldwell,

Affiliations MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Cancer Biology Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Holly Edwards,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Alan A. Dombkowski,

Affiliations Division of Pharmacology and Toxicology, Children’s Hospital of Michigan, Detroit, Michigan, United States of America, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Steven A. Buck,

Affiliations Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, Michigan, United States of America
⨯
Larry H. Matherly,

Affiliations Cancer Biology Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Yubin Ge,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Jeffrey W. Taub

* E-mail: jtaub@med.wayne.edu

Affiliations Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, Michigan, United States of America
⨯

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

John Timothy Caldwell,
Holly Edwards,
Alan A. Dombkowski,
Steven A. Buck,
Larry H. Matherly,
Yubin Ge,
Jeffrey W. Taub

Published: July 10, 2013
https://doi.org/10.1371/journal.pone.0068601

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