RNA Deep Sequencing Analysis Reveals That Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats

Junran Cao; Shaolin Wang; Ju Wang; Wenyan Cui; Tanseli Nesil; Michael Vigorito; Sulie L. Chang; Ming D. Li

doi:10.1371/journal.pone.0068517

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Peer-reviewed

Research Article

RNA Deep Sequencing Analysis Reveals That Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats

Junran Cao,

Affiliation Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Shaolin Wang,

Affiliation Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Ju Wang,

Affiliations Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America, School of Biomedical Engineering, Tianjin Medical University, Tianjin, China
⨯
Wenyan Cui,

Affiliations Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America, The First Affiliated Hospital, Zhejiang University, Hangzhou, China
⨯
Tanseli Nesil,

Affiliation Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Michael Vigorito,

Affiliations Institute of NeuroImmune Pharmacology, Seton Hall University, South Orange, New Jersey, United States of America, Department of Psychology, Seton Hall University, South Orange, New Jersey, United States of America
⨯
Sulie L. Chang,

Affiliations Institute of NeuroImmune Pharmacology, Seton Hall University, South Orange, New Jersey, United States of America, Department of Biological Sciences, Seton Hall University, South Orange, New Jersey, United States of America
⨯
Ming D. Li

* E-mail: ml2km@virginia.edu

Affiliation Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
⨯

RNA Deep Sequencing Analysis Reveals That Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats

Junran Cao,
Shaolin Wang,
Ju Wang,
Wenyan Cui,
Tanseli Nesil,
Michael Vigorito,
Sulie L. Chang,
Ming D. Li

Published: July 16, 2013
https://doi.org/10.1371/journal.pone.0068517

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HIV-1
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Prefrontal cortex
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CREB signaling
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Nicotine replacement therapy
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Gene expression
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