Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

Debebe Gebremedhin; Maia Terashvili; Nadi Wickramasekera; David X. Zhang; Nicole Rau; Hiroto Miura; David R. Harder

doi:10.1371/journal.pone.0068498

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Peer-reviewed

Research Article

Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

Debebe Gebremedhin ,

* E-mail: mariyei@mcw.edu

Affiliations Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Maia Terashvili,

Affiliations Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Nadi Wickramasekera,

Affiliations Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
David X. Zhang,

Affiliations Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Nicole Rau,

Affiliations Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Hiroto Miura,

Affiliations Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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David R. Harder

Affiliations Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Clement Zablocki VA Medical Center, Milwaukee, Wisconsin, United States of America
⨯

Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

Debebe Gebremedhin,
Maia Terashvili,
Nadi Wickramasekera,
David X. Zhang,
Nicole Rau,
Hiroto Miura,
David R. Harder

Published: July 5, 2013
https://doi.org/10.1371/journal.pone.0068498

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Superoxides
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Redox signaling
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