Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant

• Barbara Arnò,

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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• Ilda D’Annessa,

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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• Cinzia Tesauro,

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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• Laura Zuccaro,

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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• Alessio Ottaviani,

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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• Birgitta Knudsen,

  Affiliation Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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• Paola Fiorani,

  Affiliation Institute of Translational Pharmacology, National Research Council, CNR, Rome, Italy

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• Alessandro Desideri

  * E-mail: desideri@uniroma2.it

  Affiliation Department of Biology and Interuniversity Consortium, National Institute Biostructure and Biosystem (INBB), University of Rome Tor Vergata, Rome, Italy

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