The Polyphenol Fisetin Protects Bone by Repressing NF-κB and MKP-1-Dependent Signaling Pathways in Osteoclasts

Open Access

Peer-reviewed

Research Article

Laurent Léotoing,

Affiliations Clermont Université, Université d'Auvergne, Clermont-Ferrand, France, INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
⨯
Fabien Wauquier,

Affiliations Clermont Université, Université d'Auvergne, Clermont-Ferrand, France, INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
⨯
Jérôme Guicheux,

Affiliations Université de Nantes, UFR Odontologie, Nantes, France, NSERM, UMRS 791, LIOAD, Nantes, France
⨯
Elisabeth Miot-Noirault,

Affiliations Clermont Université, Université d'Auvergne, Clermont-Ferrand, France, INSERM, UMR 990, Clermont-Ferrand, France
⨯
Yohann Wittrant,

Affiliations Clermont Université, Université d'Auvergne, Clermont-Ferrand, France, INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
⨯
Véronique Coxam

* E-mail: veronique.coxam@clermont.inra.fr

Affiliations Clermont Université, Université d'Auvergne, Clermont-Ferrand, France, INRA, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
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Osteoclasts
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Transcription factors
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Cell differentiation
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Ovariectomy
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MAPK signaling cascades
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Bone density
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Inflammation
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Osteoporosis
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