Increased S-Nitrosylation and Proteasomal Degradation of Caspase-3 during Infection Contribute to the Persistence of Adherent Invasive Escherichia coli (AIEC) in Immune Cells

Karl A. Dunne; Amr Allam; Anne McIntosh; Stephanie A. Houston; Vuk Cerovic; Carl S. Goodyear; Andrew J. Roe; Scott A. Beatson; Simon W. Milling; Daniel Walker; Daniel M. Wall

doi:10.1371/journal.pone.0068386

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Open Access

Peer-reviewed

Research Article

Increased S-Nitrosylation and Proteasomal Degradation of Caspase-3 during Infection Contribute to the Persistence of Adherent Invasive Escherichia coli (AIEC) in Immune Cells

Karl A. Dunne,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Amr Allam,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Anne McIntosh,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Stephanie A. Houston,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Vuk Cerovic,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Carl S. Goodyear,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Andrew J. Roe,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Scott A. Beatson,

Affiliation School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, St. Lucia, Queensland, Australia
⨯
Simon W. Milling,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Daniel Walker,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
Daniel M. Wall

* E-mail: donal.wall@glasgow.ac.uk

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯

Increased S-Nitrosylation and Proteasomal Degradation of Caspase-3 during Infection Contribute to the Persistence of Adherent Invasive Escherichia coli (AIEC) in Immune Cells

Karl A. Dunne,
Amr Allam,
Anne McIntosh,
Stephanie A. Houston,
Vuk Cerovic,
Carl S. Goodyear,
Andrew J. Roe,
Scott A. Beatson,
Simon W. Milling,
Daniel Walker

Published: July 4, 2013
https://doi.org/10.1371/journal.pone.0068386

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S-nitrosylation
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Apoptosis
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Nitric oxide
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Ubiquitin ligases
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Gastrointestinal tract
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Macrophages
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